Process for the preparation of asenapine in the form of its free base
OwnerRené RIETSCHER, René EIFLER +1inventors
InventorsRené RIETSCHER, René EIFLER, Olga BOURQUAIN
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Abstract
The present invention relates to a process for the preparation of asenapine in the form of its free base, a process for the preparation of an active ingredient-containing layer for use in a transdermal therapeutic system, asenapine in the form of its free base, obtainable by said process for the preparation of asenapine in the form of its free base, an active ingredient-containing layer for use in a transdermal therapeutic system, obtainable by said process for the preparation of an active ingredient-containing layer and a transdermal therapeutic system containing such an active ingredient-containing layer.
Claims17
A process for the preparation of asenapine in the form of its free base comprising the steps of:
- 1) providing a reaction mixture comprising asenapine maleate and an alkali metal silicate in a solvent, wherein the reaction mixture contains the alkali metal silicate in dispersed form, and
- 2) reacting asenapine maleate with the alkali metal silicate in the reaction mixture provided in step 1) in order to obtain a product mixture which contains dissolved asenapine in the form of its free base and alkali metal maleate in dispersed form.
Dependencies are inferred from the claim text.