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US 2023/0399330 A1Published application
Solid Forms of 2-[3-[4-Amino-3-(2-Fluoro-4-Phenoxy-Phenyl)Pyrazolo[3,4-d]Pyrimidin-1-YL] Piperidine-1-Carbonyl]-4-Methyl-4-[4-(Oxetan-3-YL)Piperazin-1-YL]Pent-2-Enenitrile
AssigneePrincipia Biopharma Inc.
InventorsKolbot By, Katherine Chu, Mohammad R. Masjedizadeh, Pasit Phiasivongsa, Jiang Zhu
Life of this patent
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Abstract
Solid forms of Compound (I): are disclosed. Pharmaceutical compositions comprising the same, methods of treating disorders and conditions mediated by BTK activity using the same, and methods for making Compound (I) and solid forms thereof are also disclosed.
Claims9
1-39. (canceled)
A process for preparing an amorphous form of Compound (I):
- comprising:
- washing a solution of Compound (I) with a first aqueous acidic solution to create a first solution comprising a first organic layer and a first aqueous layer, wherein the solution of Compound (I) comprises a first organic solvent;
- removing the first aqueous layer;
- and
- performing a solvent exchange from the first organic solvent to a second organic solvent.
2 more elements
47-50. (canceled)
Dependencies are inferred from the claim text.