Dicyclopropylmethyl derivatives as il-17 modulators

A compound of formula (I) or an N-oxide thereof, or a pharmaceutically acceptable salt thereof:

• wherein
• A represents C—R1 or N;
• E represents C—R2 or N;
• Z represents a group of formula (Za), (Zb), (Zc), (Zd), (Ze) or (Zf):
• in which the asterisk (*) represents the point of attachment to the remainder of the molecule;
• Y represents O, N—R4, CR5aR5b, S, S(O), S(O)2 or S(O)(N—R7);
• R1 represents hydrogen or fluoro;
• R2 represents hydrogen or fluoro;
• R3 represents C3-9 cycloalkyl, C4-12 bicycloalkyl, C3-7 heterocycloalkyl or C4-9 heterobicycloalkyl, any of which groups may be optionally substituted by one or more substituents;
• R4 represents —COR4a, —CO2R4a or —SO2R4b;
• or R4 represents hydrogen;
• or R4 represents C1-6 alkyl or C3-9 cycloalkyl, either of which groups may be optionally substituted by one or more fluorine atoms;
• R4a represents C1-6 alkyl, optionally substituted by one or more fluorine atoms;
• R4b represents C1-6 alkyl;
• R5a represents hydrogen, fluoro, methyl, difluoromethyl or trifluoromethyl;
• and
• R5b represents hydrogen, fluoro, methyl or hydroxy;
• or
• R5a and R5b, when taken together with the carbon atom to which they are both attached, represent cyclopropyl;
• R6 represents —OR6a or —NR6bR6c;
• or R6 represents C1-6 alkyl, C3-9 cycloalkyl, C3-9 cycloalkyl(C1-6)alkyl, aryl, aryl(C1-6)alkyl, C3-7 heterocycloalkyl, C3-7 heterocycloalkyl-(C1-6)alkyl, heteroaryl or heteroaryl(C1-6)alkyl, any of which groups may be optionally substituted by one or more substituents;
• R6a represents C1-6 alkyl;
• or R6a represents C3-9 cycloalkyl, which group may be optionally substituted by one or more substituents;
• R6b represents hydrogen or C1-6 alkyl;
• R6c represents hydrogen or C1-6 alkyl;
• and
• R7 represents C1-6 alkyl.