Eif4e inhibitors and uses thereof

A method for treating a cancer in a patient comprising administering to the patient a compound of formula V:

• or a pharmaceutically acceptable salt thereof, wherein:
• each R1 is independently halogen, R, —N(R)2, —OR, —SR, —C(O)OR, or —S(O)2R;
• n is 0, 1, 2, 3, 4, or 5;
• L1 is a bond, or an optionally substituted C1-8 bivalent straight or branched hydrocarbon chain, wherein 1, 2, 3, or 4 methylene units of the hydrocarbon chain are optionally and independently replaced with —O—, —S—, —N(R)—, or —S(O)2—;
• R2 is halogen, R, —OR, —SR, —C(O)R, —C(O)OR, —C(O)N(R)2, —S(O)2R, —S(O)2OR, or —S(O)2N(R)2;
• R3 is —CN, —C(O)R, —C(O)OR, —C(O)N(R)2, —N(R)—C(O)—R, —N(R)—C(O)—OR, —S(O)2—N(R)2, —S(O)2—N(R)—C(O)R, —C(O)—N(R)—S(O)2R, —C(═NR)—N(R)2, —N(R)—C(═NR)—N(R)2, or a 5-6 membered monocyclic heteroaromatic ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, and sulfur;
• and
• R is hydrogen, optionally substituted —C1-6 aliphatic, or an optionally substituted ring selected from phenyl, a 5-6 membered monocyclic heteroaromatic ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, and sulfur, a 3-6 membered monocyclic, saturated or partially unsaturated, carbocyclic ring, or a 3-6 membered monocyclic, saturated or partially unsaturated, heterocyclic ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, and sulfur.