Compounds and methods for the treatment of ocular disorders

A compound having the structure of Formula (Ib):

• or a pharmaceutically acceptable salt or solvate (e.g., or a stereoisomer) thereof,
• wherein:
• Lz is bond, —O(C═O)(OCR8R9)z—, or —(C═O)(OCR8R9)z—;
• each R8 and R9 is independently H, halogen, C1-C3-alkyl, C1-C3-haloalkyl, C1-C3-alkoxy, C3-C5-cycloalkyl, or R8 and R9 are taken together with the atoms to which they are attached to form a C3-C5-cycloalkyl;
• z is 1-6;
• and
• Rx is:
• R1a and R1b are each independently —H or —SR1c;
• each R1c is independently substituted or unsubstituted (e.g., straight or branched) alkyl (e.g., substituted with one or more (alkyl) substituent, each (alkyl) substituent being independently selected from the group consisting of carboxylic acid, —SH, thioalkyl, acetamide, amino, oxo, and optionally substituted heterocycloalkyl (e.g., N-attached pyrrolidinyl substituted with —COOH)) or substituted or unsubstituted (e.g., straight or branched) heteroalkyl (e.g., substituted with one or more (heteroalkyl) substituent, each (heteroalkyl) substituent being independently selected from the group consisting of carboxylic acid, amino, thioalkyl, thiol, acetamide, and C1-C3 alkyl);
• each R2a, R2b, R2c, R2d, R2e, and R2f is independently H, halogen, C1-C3-alkyl, C1-C3-haloalkyl, C1-C3-alkoxy, C3-C5-cycloalkyl, or two of R2a and R2b, R2e and R2d, or R2e and R2f are taken together with the atoms to which they are attached to form a C3-C5-cycloalkyl;
• m is an integer from 1-10;
• and
• n and o are each independently an integer from 1-3.

A compound having the structure of Formula (Ic):

• or a pharmaceutically acceptable salt or solvate (e.g., or a stereoisomer) thereof,
• wherein:
• Lz is bond, —O(C═O)(OCR8R9)z—, or —(C═O)(OCR8R9)z—;
• each R8 and R9 is independently H, halogen, C1-C3-alkyl, C1-C3-haloalkyl, C1-C3-alkoxy, C3-C5-cycloalkyl, or R8 and R9 are taken together with the atoms to which they are attached to form a C3-C5-cycloalkyl;
• z is 1-6;
• and
• Ry is:
• each R4a and R4b is independently H, halogen, or substituted or unsubstituted alkyl;
• p is an integer from 1-10;
• and
• q is an integer from 1-3.

A compound having the structure of Formula (Id):

• or a pharmaceutically acceptable salt or solvate (e.g., or a stereoisomer) thereof,
• wherein:
• Lz is bond, —O(C═O)(OCR8R9)z—, or —(C═O)(OCR8R9)z—;
• each R8 and R9 is independently H, halogen, C1-C3-alkyl, C1-C3-haloalkyl, C1-C3-alkoxy, C3-C5-cycloalkyl, or R8 and R9 are taken together with the atoms to which they are attached to form a C3-C5-cycloalkyl;
• z is 1-6;
• and
• Rz is:
• R5 is —SR1c;
• R1c is substituted or unsubstituted (e.g., straight or branched) alkyl (e.g., substituted with one or more (alkyl) substituent, each (alkyl) substituent being independently selected from the group consisting of carboxylic acid, —SH, thioalkyl, acetamide, amino, oxo, and optionally substituted heterocycloalkyl (e.g., N-attached pyrrolidinyl substituted with —COOH)), or substituted or unsubstituted (e.g., straight or branched) heteroalkyl (e.g., substituted with one or more (heteroalkyl) substituent, each (heteroalkyl) substituent being independently selected from the group consisting of carboxylic acid, amino, thioalkyl, thiol, acetamide, and C1-C3 alkyl);
• R6 and R7 are each independently H, substituted or unsubstituted alkyl, or substituted or unsubstituted heteroalkyl;
• each R10 and R11 is independently H, halogen, C1-C3-alkyl, C1-C3-haloalkyl, C1-C3-alkoxy, C3-C5-cycloalkyl, or two of R10 and R11 are taken together with the atoms to which they are attached to form a C3-C5-cycloalkyl;
• and
• s is an integer from 1-10.