Cd73 inhibitor and use thereof

A compound represented by formula I, or a tautomer, stereoisomer, hydrate, solvate, pharmaceutically acceptable salt, or prodrug thereof:

• wherein:
• R1 is selected from
• wherein Ra is independently selected from hydrogen, C1-C6 alkyl, C3-C6 cycloalkyl, five- to eight-membered aryl, five- to eight-membered heteroaryl, four- to eight-membered heterocycloalkyl, or C1-C6 alkyl substituted with 1 to 5 identical or different halogen atoms, wherein the five- to eight-membered heteroaryl contains 1 to 3 heteroatoms selected from one or more of N, S, O, and P;
• and the four- to eight-membered heterocycloalkyl contains 1 to 3 heteroatoms selected from one or more of N, S, O, and P;
• and the four- to eight-membered heterocycloalkenyl contains 1 to 3 heteroatoms selected from one or more of N, S, O, and P;
• and
• R2 is selected from hydrogen, halogen, hydroxyl, cyano, amino, C1-C6 alkyl unsubstituted or substituted with Rb, (C1-C6 alkyl)-O— unsubstituted or substituted with Rb, (C1-C6 alkyl)-S-unsubstituted or substituted with Rb, five- to eight-membered aryl unsubstituted or substituted with Rb, five- to eight-membered heteroaryl unsubstituted or substituted with Rb, four- to eight-membered heterocycloalkyl unsubstituted or substituted with Rb, four- to eight-membered heterocycloalkenyl unsubstituted or substituted with Rb, or C2-C6 alkenyl unsubstituted or substituted with Rb, wherein, in the C1-C6 alkyl substituted with Rb, the (C1-C6 alkyl)-O-substituted with Rb, the (C1-C6 alkyl)-S— substituted with Rb, the five- to eight-membered aryl substituted with Rb, the five- to eight-membered heteroaryl substituted with Rb, the four- to eight-membered heterocycloalkyl substituted with Rb, the four- to eight-membered heterocycloalkenyl substituted with Rb, and the C2-C6 alkenyl substituted with Rb, one or more Rb substituents are present and each independently selected from halogen, hydroxyl, cyano, amino, C1-C6 alkyl, C3-C6 cycloalkyl, or (C1-C6 alkyl)-O—, wherein when more than one substituents are present, the more than one substituent groups are identical or different;
• and wherein the five- to eight-membered heteroaryl unsubstituted or substituted with Rb contains 1 to 3 heteroatoms selected from one or more of N, S, O, and P;
• the four- to eight-membered heterocycloalkyl unsubstituted or substituted with Rb contains 1 to 3 heteroatoms selected from one or more of N, S, O, and P;
• and the four- to eight-membered heterocycloalkenyl unsubstituted or substituted with Rb contains 1 to 3 heteroatoms selected from one or more of N, S, O and P.