Method for selectively synthesizing 3,6'-dithiopomalidomide from pomalidomide

Abstract

In a method of synthesizing 3,6′-dithiopomalidomide from pomalidomide according to an embodiment, pomalidomide is dissolved by adding a solvent thereto, phosphorus pentasulfide (P2S5) is added to the dissolved pomalidomide, followed by stirring, and solids are removed from the stirred solution, followed by purification. It is possible to reduce the production of 1,6-dithiopomalidomide, which is a by-product produced during the synthesis of 3,6′-dithiopomalidomide, and selectively increase the proportion of 3,6-dithiopomalidomide among synthesized isomeric compounds to 90% or more, thereby reducing the time and cost required to separate 1,6-dithiopomalidomide by HPLC, etc. in a subsequent purification process, thereby increasing the production and economic feasibility of the 3,6′-dithiopomalidomide compound.