Covalent inhibitors of creatine kinase (ck) and uses thereof for treating and preventing cancer

A compound of Formula I:

• or a pharmaceutically acceptable salt thereof, wherein
• A is a five or six membered aryl or heteroaryl ring;
• E is an electrophile;
• X1 is a bond, O, NR3A, CR3AR3B, or S;
• R1A is alkyl, alkyloxy, cycloalkyloxy, aryloxy, heteroaryloxy, amino, cycloalkyl, heterocyclyl, aryl, heteroaryl, aralkyl, heteroaralkyl, acyl, amide, ester, urea, or carbamate;
• or R1A and R1B combine to form a cycloalkyl or heterocyclyl;
• R1B, R2A, R2B, R3A, and R3B are each independently selected from H, alkyl, aralkyl, acyl, amide, carboxyl, ester, and carbamate;
• R4 is alkyl, alkenyl, alkynyl, halo, hydroxyl, carboxyl, acyl, acetyl, ester, thioester, alkoxy, phosphoryl, amino, amide, cyano, nitro, azido, alkylthio, cycloalkyl, cycloalkylalkyl, heterocyclylalkyl, heteroaralkyl, sulfonamide, aryl, heteroaryl, heterocyclyl, or aralkyl;
• and
• n is 0-5.