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US 2023/0399296 A1Published application
Rna virus inhibitor compounds with improved metabolic stability and uses thereof
OwnerJames A. Nieman, M. Joanne Lemieux +7inventors
InventorsJames A. Nieman, M. Joanne Lemieux, Elena Arutyunova, Michael A. Joyce, D. Lorne Tyrrell, Holly Saffran, Bing Bai, Mostofa Hena, Appan Srinivas Kandadai
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Abstract
The present disclosure provides compounds with increased metabolic stability for inhibiting a virus infection, such as a Baltimore Group IV RNA virus infection, such as rhinovirus, coxsackievirus, norovirus and coronavirus. Aspects of the present disclosure also include methods of treating the virus infection in a subject with compounds with increased metabolic stability.
Claims40
A compound of formula (I):
- wherein:
- each R1 is independently selected from —H, —F, —Cl and —CH3;
- R2 is selected from —Cl and —F;
- R3 is selected from —CH2CH3, —CH(CH3)2, —C(CH3)3, —CF(CH3)2, —CF2CH3, —CH(CF3)CH3, —CH2CCl2H, —CH2CF3, —CH(CF3)2, cyclopropyl and cyclohexyl;
- R4 is selected from —H, —P(═O)(OH)2, —C(═O)CH(NH2)CH(CH3)2 and —C(═O)CH2NH2;
- X is selected from —CH2—, —CDH— and —CD2-;
- and
- Y is —CH2— or is absent;
- or a pharmaceutically acceptable salt, solvate, or hydrate thereof.
6 more elements
Dependencies are inferred from the claim text.