Compositions for increasing tissue regeneration and delaying or reducing granuloma formation

Abstract

Disclosed are compounds and methods to enhance the resolution of inflammation and inflammatory diseases comprising novel compounds derived from conjugated specialized pro-resolving lipid mediators (SPMs). These compounds are useful in preventing and treating granuloma formation and subsequent loss of tissue regeneration and organ function. The compounds are 5 amino conjugates of Resolvin D3 and Resolvin D4 with glutathione. Further identified are novel glutathione-conjugated specialized pro-resolving lipid mediators. These newly identified cysteinyl-SPM significantly increased the amount of tissue regenerated (p<0.05) and accelerated the speed of regeneration by ˜24 h in Planarian regeneration. Together, these results provide evidence for a 4(5) epoxide resolvin pathway in the biosynthesis of novel 4,5 cysteinyl-SPMs that reduce granuloma and are useful for treating or preventing diseases including Mycobacterium tuberculosis, chronic granulomatous disease, granulomatous steatitis, foreign-body granulomas, interstitial lung fibrosis (ipf), leprosy, arthritis, sarcoidosis, liver fibrosis, heart fibrosis, renal fibrosis, hepatic cirrhosis, pulmonary fibrosis and organ fibrosis.

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