Series of Skin-Whitening (Lightening) Compounds
AssigneeUnigen, Inc.
InventorsSandip K. Nandy, Jiyun Liu, Alexandre Mikhailovitch Nesterov, Carmen Hertel, Abeysinghe Arrachchigae Papmapiya
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Abstract
The present invention is directed to inhibitors of tyrosinase, pharmaceutical compositions comprising such tyrosinase inhibitors, and methods of making and using the same. Specifically, included in the present invention are compositions of matter comprised of at least one 2,4-dihydroxybenzene analog, which inhibit the activity of tyrosinase and which inhibit the overproduction of melanin.
Claims6
1-65:
- (canceled)
A compound of Formula V:
- or a pharmaceutically acceptable salt thereof, wherein:
- R1 is selected from the group consisting of H or C1-C10 alkyl;
- Bn is a benzyl;
- and
- R′ is 1 to 3 moieties (R′, R″, R′″) independently selected from the group consisting of a C1-C10 alkyl group, a C1-C10 alkoxy group or a hydroxyl group.
A composition comprising the compound of claim 61 and a pharmaceutically or cosmetically acceptable carrier.
A method of producing the compound in claim 61 by utilizing a compound comprising Formula IV as a starter compound or an intermediate compound:
- wherein represents double or single bond,
- R1 is selected from the group consisting of H or C1-C10 alkyl;
- R4 is selected from the group consisting of ═H, OH or O;
- and
- R5 is a selected from the group consisting of a substituted or unsubstituted:
- aromatic ring, heteroaromatic ring, heterocyclic ring or a hydroxylalkyl moiety.
Dependencies are inferred from the claim text.