US 2023/0398381 A1 · MULTIPARAMETRIC OPTIMIZATION FOR ULTRASOUND PROCEDURES

Abstract

Focused-ultrasound systems and methods involve simultaneously determining multiple ultrasound parameters (e.g., applied acoustic power, frequency, phases, position, activation pattern, beam shape, wave shape, etc.) associated with the transducer array for generating optimal treatment effects both at the target region (e.g., causing a sufficient temperature increase for tissue necrosis to occur) and non-target region (e.g., having a clinically insignificant temperature increase to avoid damage to the non-target tissue). A computational model may simulate the treatment effects (e.g., the temperature, peak intensity, focus shape, location of the hot spot, etc.) of these ultrasound parameters on the target and/or non-target regions. Based on the simulation results, the computational model may simultaneously determine the optimal values of the multiple ultrasound parameters—i.e., the values that, while not necessarily optimal for each individual parameter considered in isolation, nonetheless produce optimal overall treatment effects at the target and non-target

Claims19

Dependent claims

A system for delivering ultrasound energy to a target region, the system comprising:

an ultrasound transducer comprising a plurality of transducer elements for generating a focal zone of acoustic energy at the target region;
at least one measurement system for measuring a plurality of treatment effects at the target region and/or a non-target region;
and
a controller configured to:
(a) computationally determine values of ultrasound parameters associated with at least some of the transducer elements and predict the treatment effects at the target region and/or the non-target region;
(b) operate the ultrasound transducer based at least in part on the determined values of ultrasound parameters;
(c) cause the at least one measurement system to measure at least some of the treatment effects at the target region and/or the non-target region;
(d) compare the measured treatment effects against the predicted treatment effects;
(e) based on the comparison, computationally update the values of at least some of the ultrasound parameters;
and
(f) operate the ultrasound transducer based at least in part on the updated values of ultrasound parameters.

8 more elements

Dependencies are inferred from the claim text.

Multiparametric optimization for ultrasound procedures

Life of this patent

Multiparametric optimization for ultrasound procedures

Life of this patent

Abstract

Claims19