Systems and methods for treating gastrointestinal dysmotility
AssigneesDuke University, Flinders Medical Center
InventorsWarren Grill, Bradley Barth, Nick Spencer
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Abstract
The present disclosure provides systems and methods relating to the treatment of gastrointestinal dysmotility. In particular, the present disclosure provides systems and methods for delivering temporal patterns of electrical stimulation with respect to a refractory period to either suppress (e.g., treat hypermotility) or stimulate (e.g., treat hypomotility) contractions and motility in the gastrointestinal tract of a subject.
Claims27
A method of treating gastrointestinal dysmotility in a subject, the method comprising:
- applying at least one temporal pattern of electrical stimulation to a target nerve or a set of target nerves in a subject having at least one symptom of a gastrointestinal hypermotility disorder and/or a hypomotility disorder;
- wherein the application of the at least one temporal pattern of electrical stimulation prior to a refractory period suppresses contractions and motility, thereby treating the hypermotility disorder;
- and/or
- wherein the application of the at least one temporal pattern of electrical stimulation after a refractory period stimulates contractions and motility, thereby treating the hypomotility disorder.
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A method of treating gastrointestinal dysmotility in a subject, the method comprising:
- programming a pulse generator to output at least one temporal pattern of electrical stimulation to a target nerve or set of target nerves in a subject having at least one symptom of a gastrointestinal hypermotility disorder and/or a hypomotility disorder;
- and
- delivering the at least one temporal pattern of electrical stimulation to the subject prior to a refractory period to suppress contractions and motility, thereby treating the hypermotility disorder;
- and/or
- delivering the at least one temporal pattern of electrical stimulation to the subject after a refractory period to stimulate contractions and motility, thereby treating the hypomotility disorder.
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Dependencies are inferred from the claim text.