US 2023/0398265 A1 · COMPOSITIONS AND METHODS FOR INHIBITION OF TISSUE ADHESION

Abstract

The present disclosure provides compositions and methods for inhibition of tissue adhesion. According to specific aspects, implantable anti-adhesion zwitterionic compositions which include: an aqueous liquid; and a zwitterionic polymer are disclosed, wherein the zwitterionic polymer is, consists essentially of, or includes, poly(3-((3-acrylamidopropyl)dimethylammonio)propanoate) (PCBAA). According to specific aspects, implantable anti-adhesion zwitterionic compositions are provided which include nanoparticles and/or microparticles of zwitterionic hydrogel, wherein the zwitterionic hydrogel is, consists essentially of, or includes, PCBAA. Methods of inhibiting tissue adhesion in a subject in need thereof are provided according to aspects of the present disclosure which include administering an implantable anti-adhesion zwitterionic composition to a tissue surface exposed by surgery.

Claims24

Dependent claims

-14. (canceled)

A packaged dosage unit of an implantable anti-adhesion zwitterionic composition, comprising:

an aqueous liquid and a zwitterionic polymer or copolymer, the zwitterionic polymer or copolymer comprising a plurality of repeating units, where each repeating unit has structural formula (VI), (VIII), or (X):
where M is a monomeric repeating unit, n is an integer from 1 to about 100,000, where R2, and R3 are each independently selected from hydrogen, alkyl, and aryl groups, L1 is a linker that covalently couples a cationic center to a polymer backbone;
L2, if present, is a linker that covalently couples the cationic center to an anionic group;
A(═O)O−, if present, is an anionic group, X−, if present, is a counter ion associated with the cationic center, and Y+, if present, is a metal ion, an ammonium ion, or an organic ion.

1 more element

Dependencies are inferred from the claim text.

Facts

Application

18/252,416Filed 9 Nov 2021

Priority

10 Nov 2020

Published

14 Dec 2023

Term ends

Not estimatedThe source records don’t support an estimate.

Classification9 codes

A61L 31/06
Macromolecular materials: obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
A61L 31/14
Materials for other surgical articles , e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention,…:…
A61K 9/0024
Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in…
A61K 47/34
Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates: macromolecular compounds obtained otherwise than by reactions only…

Compositions and methods for inhibition of tissue adhesion

Life of this patent

Compositions and methods for inhibition of tissue adhesion

Life of this patent

Abstract

Claims24