Tissue Protective Hydrogel
AssigneeETH Zurich
InventorsMaryam Asadikorayem, Marcy Zenobi-Wong, Patrick Christian Weber, Frantisek Surman
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Abstract
The present invention relates to the medical use of a zwitterionic antifouling hydrogel. The hydrogel may be used in prevention of and protection against inflammation of tissue or in stabilization of a tissue implant.
Claims20
A method for treating a condition associated with tissue inflammation, comprising the step of administering a zwitterionic hydrogel composition to a patient in need thereof, said composition comprising, or essentially consisting of:
- a polymer consisting of:
- i. a plurality of zwitterionic first subunits;
- and
- ii. a plurality of crosslinkable second subunits;
- wherein the first subunits comprise
- d. a positively charged moiety;
- e. a negatively charged moiety;
- and
- f. a polymer backbone moiety.
A coating composition for coating of a tissue implant, said coating composition comprising or essentially consisting of:
- a zwitterionic hydrogel forming polymer consisting of:
- i. a plurality of zwitterionic first subunits comprising a positively charged moiety, a negatively charged moiety, and a polymer backbone moiety;
- ii. a plurality of crosslinkable second subunits selected from the group consisting of tyramine, phenol, catechol, and resorcinol.
A method of providing a composition for use as coating of a tissue implant, comprising the steps of:
- a. providing an aqueous solution of a zwitterionic hydrogel-forming polymer, said zwitterionic hydrogel-forming polymer consisting of:
- i. a plurality of zwitterionic first subunits comprising a positively charged moiety, a negatively charged moiety, and a polymer backbone moiety;
- ii. a plurality of crosslinkable second subunits selected from the group consisting of tyramine, phenol, catechol, and resorcinol.
- b. providing a tissue implant selected from:
- i. a cartilage implant, particularly an articular or an auricular implant;
- ii. a heart valve prosthesis;
- iii. a vasculature graft,
- iv. a decellularized allograft or xenograft.
- c. crosslinking said crosslinkable second subunits,
- to obtain a coated tissue implant.
Dependencies are inferred from the claim text.