System for focused targeting of magneto-aerotactic-responsive bacteria and method of use thereof
AssigneeStarpax Biopharma Inc.
InventorSylvain Martel
Life of this patent
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Abstract
A method of improving targeted delivery of at least one of a treatment agent, an imaging agent and a diagnostic agent attached to magneto-aerotactic-responsive bacteria; it includes adapting a total bolus escape time of a solution of the magneto-aerotactic responsive bacteria in order to influence the targeting of a target zone with hypoxic zones in the patient.
Claims15
A method of improving targeted delivery of at least one of a treatment agent, an imaging agent and a diagnostic agent attached to magneto-aerotactic-responsive bacteria adapted to self-locomote while subject to a magnetic field, the magneto-aerotactic-responsive bacteria depositing the at least one of a treatment agent, an imaging agent and a diagnostic agent at hypoxic zones in a patient, comprising:
- adapting a total bolus escape time of a solution of the magneto-aerotactic responsive bacteria when injected into the patient in order to influence the targeting of a target zone with hypoxic zones in the patient, wherein decreasing the total bolus escape time favors a targeting, by the magneto-aerotactic-responsive bacteria, of one or more of the hypoxic zones at a farther distance from an injection site of the magneto-aerotactic-responsive bacteria while considering a decrease in velocity post-injection of said magneto-aerotactic-responsive bacteria when exposed to an environment of said patient.
A method of influencing a total bolus escape time of a solution of magneto-aerotactic-responsive bacteria attached to at least one of a treatment agent, an imaging agent and a diagnostic agent for injection into a patient, wherein the magneto-aerotactic-responsive bacteria is adapted to self-locomote while subject to a magnetic field, the magneto-aerotactic-responsive bacteria depositing the at least one of a treatment agent, an imaging agent and a diagnostic agent at a target zone with hypoxic zones in a patient, comprising:
- at least one of increasing the surface-volume ratio of the bolus, decreasing the concentration of the magneto-aerotactic-responsive bacteria in the solution, decreasing the viscosity of the solution, and increasing the surface of the bolus exposed to the north of the magnetic field for north-seeking magneto-aerotactic-responsive bacteria and to the south of the magnetic field for south-seeking magneto-aerotactic-responsive bacteria, that is to decrease the total bolus escape time of the magneto-aerotactic-responsive bacteria;
- or
- at least one of decreasing the surface-volume ratio of the bolus, increasing the concentration of the magneto-aerotactic-responsive bacteria in the solution, increasing the viscosity of the solution, and decreasing the surface of the bolus exposed to the north of the magnetic field for north-seeking magneto-aerotactic-responsive bacteria and to the south of the magnetic field for south-seeking magneto-aerotactic-responsive bacteria, that is to increase the total bolus escape time of the magneto-aerotactic-responsive bacteria,
- whereby a lower total bolus escape time of the magneto-aerotactic responsive bacteria is for targeting one or more of the hypoxic zones of the target zone in said patient that are further from said injection site.
Dependencies are inferred from the claim text.