Modulating th1/th2 immune response by administering two populations of polymersomes having an associated antigen and an associated adjuvant

A method of modulating an immune response in a subject, wherein said immune response comprising a Th1 immune response and a Th2 immune response, by administering an antigen and an adjuvant, wherein the antigen is associated with a first population of polymersomes, wherein the adjuvant is associated with a second population of polymersomes, wherein the adjuvant associated with in the second population of polymersomes is selected from the group consisting of a CpG oligodeoxynucleotide (or CpG ODN), components derived from bacterial and mycobacterial cell wall and proteins, wherein the two populations of polymersomes are administered to the subject, and wherein administering of the two separate populations modulates said immune response by increasing the number of CD4+ T cells that express one or more Th1 cytokines selected from the group consisting of IFNγ, TNFα, IL-2 and IL-12 compared to administering to the subject the adjuvant in a free form and/or compared to administering the antigen alone when associated with a first population of polymersomes.