Gene shuffled lyssavirus vaccine
AssigneeThomas Jefferson University
InventorsMatthias Johannes Schnell, Christoph Wirblich
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Abstract
The present invention includes a vaccine comprising a nucleic acid comprising (a) a nucleotide sequence encoding a rabies virus nucleoprotein (N) or a portion thereof and (b) a nucleotide sequence encoding a glycoprotein (G) (e.g., a RABV glycoprotein, a MOKV glycoprotein, or a chimeric MOKV/RABY glycoprotein), or a portion thereof positioned immediately 3′ to the nucleoprotein (N) gene sequence.
Claims48
An isolated nucleic acid encoding a recombinant lyssavirus comprising a nucleotide sequence encoding at least a portion of the genome of a rabies virus, wherein the at least a portion of the genome of the rabies virus comprises (a) a nucleotide sequence encoding a rabies virus nucleoprotein (N) or a portion thereof and wherein the recombinant lyssavirus further comprises (b) a nucleotide sequence encoding a glycoprotein (G) or a portion thereof positioned immediately 3′ to the nucleotide sequence encoding the nucleoprotein (N).
An isolated nucleic acid comprising (a) a nucleotide sequence encoding a rabies virus nucleoprotein (N) or a portion thereof and (b) a nucleotide sequence encoding a glycoprotein (G) or a portion thereof positioned immediately 3′ to the nucleotide sequence encoding the nucleoprotein (N).
A recombinant virus encoded by a nucleic acid sequence comprising at least a portion of the genome of the rabies virus, wherein the at least a portion of the genome of the rabies virus comprises (a) a nucleotide sequence encoding a rabies virus nucleoprotein (N) or a portion thereof and wherein the nucleic acid sequence further comprises (b) a nucleotide sequence encoding a glycoprotein (G) or a portion thereof positioned immediately 3′ to the nucleotide sequence encoding the nucleoprotein (N).
Dependencies are inferred from the claim text.