Modified chikungunya viruses and sindbis viruses and uses thereof
OwnerNathaniel Stephen WANG, Shigeki Joseph MIYAKE-STONERinventors
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Abstract
The present disclosure relates to the field of molecular virology, including nucleic acid molecules comprising modified viral genomes or replicons, pharmaceutical compositions containing the same, and the use of such nucleic acid molecules and compositions for production of desired products in cell cultures or in a living body. Also provided are methods for eliciting an immune response in a subject in need thereof, as well as methods for preventing and/or treating various health conditions.
Claims21
1-54. (canceled)
A nucleic acid construct comprising a nucleic acid sequence encoding (i) a modified Chikungunya Virus (CHIKV) genome or replicon RNA or (ii) a modified Sindbis Virus (SINV) genome or replicon RNA, wherein the modified genome or replicon RNA is devoid of at least a portion of the nucleic acid sequence encoding one or more Viral structural proteins.
Dependencies are inferred from the claim text.