Compositions and methods for enhancing t cell penetration of tumors and cancers

A method for treating a tumor and/or cancer, optionally a gastrin-associated tumor and/or cancer and/or a gastrin-responsive tumor and/or cancer, in a subject, the method comprising:

• (a) administering to the subject a first composition comprising, consisting essentially of, or consisting of a conjugate comprising, consisting essentially of, or consisting of a gastrin immunogen conjugated to an immunogenic carrier, optionally conjugated via a linker, in an amount and via a route sufficient to enhance anti-tumor and/or anti-cancer T cell entry into the tumor and/or cancer;
• and
• (b) administering to the subject a second compositions comprising an anti-tumor and/or anti-cancer T cell, wherein the anti-tumor and/or anti-cancer T cell optionally comprises a chimeric antigen receptor (CAR) that binds to a tumor-associated and/or cancer-associated antigen present on the tumor and/or the cancer,
• whereby the tumor and/or the cancer is treated.

A method for sensitizing a solid tumor and/or cancer in a subject to a chimeric antigen receptor-T (CAR-T) cell therapy, the method comprising:

• (a) administering to the subject a first composition comprising, consisting essentially of, or consisting of a conjugate comprising, consisting essentially of, or consisting of a gastrin immunogen conjugated to an immunogenic carrier, optionally conjugated via a linker, in an amount and via a route sufficient to enhance entry of the CAR-T cell into the solid tumor and/or cancer;
• and
• (b) administering to the subject a second composition comprising, consisting essentially of, or consisting of a CAR-T cell that is targeted against an antigen present within the solid tumor and/or cancer,
• whereby the solid tumor and/or cancer in the subject is sensitized to the CAR-T cell therapy.