Solid cyclosporin a and dispersion composition comprising same

A dispersion composition comprising:

• a dispersion medium;
• and particles comprising a target substance,
• wherein the dispersion composition comprises at least one type of surfactant having a critical micelle concentration or more,
• the dispersion composition does not comprise a solubilizer,
• the target substance is cyclosporin A,
• if the dispersion composition comprises at least one type of surfactant, the S-parameter of Equation 3 calculated by Equation 1 and Equation 2 satisfies S-parameter >1, and
• if the dispersion composition comprises at least two types of surfactants having a critical micelle concentration or more, Ssurf(i) obtained by Equation 4 below is calculated for each type of surfactant, and then the Ssurf value is obtained as the sum of these by Equation 5 below and the S-parameter of Equation 3 obtained by applying the calculated Ssurf value to Equation 1 above satisfies S-parameter >1:
• Smicelle=Sw+Ssurf <Equation 1>
• wherein Sw is the concentration corresponding to the saturation solubility of the target substance in the dispersion medium, and Ssurf is calculated by Equation 2 below,
• Ssurf=k(Csurf−CMC) <Equation 2>
• wherein k is the molar solubilization capacity defined as the number of moles of the target substance that can be dispersed in the dispersion medium by one type of surfactant having the critical micelle concentration of 1 mole or more, and Csurf is the molar concentration of the surfactant component in the composition, and CMC is the critical micelle molar concentration of the surfactant in the composition,
• S-parameter=Stot/Smicelle <Equation 3>
• wherein Stot is the total molar content of the target substance contained in the dispersion composition,
• Ssurf(i)=ksurf(i)(Csurf(i)−CMCsurf(i)) <Equation 4>
• wherein ksurf(i) is a molar solubilization capacity defined as the number of moles of the target substance that can be dispersed in the dispersion medium by any one type of the surfactant components having the critical micelle concentration of 1 mole or more, Csurf(i) is the concentration of any one of the surfactant components having the critical micelle concentration or more, and CMCsurf(i) is the critical micelle concentration in the dispersion medium of any one type of the surfactant components having the critical micelle concentration or more, and
• S
• surf
• =
• ∑
• i
• =
• 1
• m
• S
• surf
• ⁡
• (
• i
• )
• <Equation 5>
• wherein m is the total number of types of surfactant components having the critical micelle concentration or more.