Pseudo-ternary phase system for improving solubility of a pharmaceutically active ingredient
AssigneeHepion Pharmaceuticals, Inc.
InventorsDaniel Joseph Trepanier, Daren Raymond Ure, Robert Thomas Foster
Life of this patent
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Abstract
The present disclosure relates to a pseudo-ternary phase system for improving solubility of a pharmaceutically active ingredient.
Claims20
A pseudo-ternary phase system for improving solubility of a pharmaceutically active ingredient, the pseudo-ternary phase system comprising at least one surfactant, at least one oil, and at least one cosolvent, wherein a pharmaceutically active ingredient is dispersed at a concentration greater than the solubility of the pharmaceutically active ingredient alone the aqueous solution, and wherein (a) the at least one surfactant is selected from the group consisting of Tween® 80, Tween® 40, Tween® 20, Lauroglycol™ 90, Labrasol®, Cremophor® RH40, Cremophor® EL, Labrafil® M2125, Labrafil® 1944, Span® 80, and Capryol™, (b) the at least one oil is selected from the group consisting of Peceol™, Miglyol 812, Maisine® CC, Vitamin E, Castor Oil, and Labrafac™ WL 1349, and (c) the at least one cosolvent is selected from the group consisting of propylene glycol, Transcutol®, PEG 400, ethanol, and dimethyl sulfoxide.
Dependencies are inferred from the claim text.