US 2023/0398152 A1 · MESENCHYMAL STEM CELLS CO-EXPRESSING CXCR4 AND IL-10 AND USES THEREOF

Mesenchymal stem cells co-expressing cxcr4 and il-10 and uses thereof

AssigneesFundación Instituto de Invesstigación Sanitaria Fundación Jiménez Diaz, Centeo de Investigaciones Energéticas, Medioambientales y Tecnológicas, O.A., M.P., Consorcio Centro De InvestigacióN BioméDica En Red

InventorsRosario Hervas-Salcedo, Damian García-olmo, Mariano García-Arranz, Miriam Hernando Rodríguez, Juan Antonio Bueren Roncero, Rosa Yáñez González, Maria Femández García, Mercedes López Santalla, Marina Immaculada Garin Ferreira

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Abstract

The present invention refers to mesenchymal stem cells (MSCs) characterized in that they are transduced with an integrative expression vector in order to stably co-express the chemokine receptor type 4 CXCR4 and the interleukin EL-10. The present invention also refers to the use of said MSCs as a medicament, particularly in the treatment of inflammatory and/or autoimmune diseases.

Claims17

Dependent claims

A DNA expression cassette comprising:

a. A promoter;
b. A sequence encoding the chemokine receptor type 4 CXCR4;
and
c. A sequence encoding interleukin IL-10.

1 more element

Dependencies are inferred from the claim text.