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AssigneesAmgen Inc., Amgen Research (Munich) GmbH
InventorsAdam B. MCCULLOUGH, Hosein KOUROS-MEHR, Peter KUFER, Mark SALVATI, Alexander C. MINELLA, Dirk NAGORSEN, Vijay UPRETI, Mukul MINOCHA, Brett HOUK
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The present invention relates to methods for administering therapeutic doses of bispecific T-cell engaging molecules for the treatment of cancer in a patient. The administration methods reduce the incidence and/or severity of adverse events, such as cytokine release syndrome, and entail administering to a patient a priming dose of the bispecific T-cell engaging molecule by continuous intravenous infusion over a period of days followed by administration of a therapeutic dose of the bispecific T-cell engaging molecule by a bolus intravenous infusion at dosing intervals of at least a week.
A method for administering a therapeutic dose of a bispecific T-cell engaging molecule to a patient diagnosed with cancer, comprising administering to the patient an initiation cycle of the bispecific T-cell engaging molecule, said initiation cycle comprising:
A bispecific T-cell engaging molecule that specifically binds to a target cancer cell antigen and human CD3 for use in a method for treating cancer in a patient in need thereof, wherein the method comprises administering to the patient an initiation cycle of the bispecific T-cell engaging molecule, said initiation cycle comprising:
Use of a bispecific T-cell engaging molecule that specifically binds to a target cancer cell antigen and human CD3 for the manufacture of a medicament for the treatment of cancer in a patient in need thereof, wherein the treatment comprises administering to the patient an initiation cycle of the bispecific T-cell engaging molecule, said initiation cycle comprising:
Dependencies are inferred from the claim text.