Methods for lowering hba1c level with a combination of a bet bromodomain inhibitor and a sodium dependent glucose transport 2 inhibitor

A method for lowering glycated hemoglobin (HbA1c) level to treat and/or prevent a diabetes-related disease or disorder, the method comprising administering to a subject in need thereof, a combination of a sodium-glucose transport protein 2 (SGLT2) inhibitor and a compound of Formula I:

• or a stereoisomer, tautomer, pharmaceutically acceptable salt, or hydrate thereof,
• wherein:
• R1 and R3 are each independently selected from alkoxy, alkyl, amino, halogen, and hydrogen;
• R2 is selected from alkoxy, alkyl, alkenyl, alkynyl, amide, amino, halogen, and hydrogen;
• R5 and R7 are each independently selected from alkyl, alkoxy, amino, halogen, and hydrogen;
• R6 is selected from amino, amide, alkyl, hydrogen, hydroxyl, piperazinyl, and alkoxy;
• W is selected from C and N, wherein:
• if W is N, then p is 0 or 1, and
• if W is C, then p is 1;
• and
• for W—(R4)p, W is C, p is 1 and R4 is H, or W is N and p is 0.