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US 2023/0398100 A1Published application
Methods of treating intraocular pressure with activators of tie-2
AssigneeEyePoint Pharmaceuticals, Inc.
InventorKevin PETERS
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Abstract
Disclosed herein are compounds effective for activation of Tie-2 and inhibition of HPTP-beta. The compounds can provide effective therapy for eye conditions associated with angiogenesis, for example, intraocular pressure, ocular hypertension, and glaucoma.
Claims24
A method for treating glaucoma in a subject in need thereof, the method comprising administering to the subject a therapeutically-effective amount of a Tie-2 activator, wherein:
- the administration reduces the intraocular pressure by about 0.1 mmHg to about 9 mmHg compared to absence of administration;
- the subject expresses Ang-1 and Ang-2;
- the subject is human;
- and
- the Tie-2 activator is a compound of the formula:
- or a pharmaceutically-acceptable salt, tautomer, or zwitterion thereof.
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Dependencies are inferred from the claim text.