Anti-methanogenic lovastatin analogs or derivatives and uses thereof
AssigneeCedars-Sinai Medical Center
InventorsMark Pimentel, Vince Wacher
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Abstract
The present invention relates to, in part, methods for the treatment of methanogen-associated disorders such as, for example, Irritable Bowel Syndrome (IBS) using at least one anti-methanogenic lovastatin analog or derivative. In addition, modified-release formulations comprising at least one anti-methanogenic lovastatin analog or derivative are provided which release the anti-methanogenic lovastatin analog or derivative in the gastrointestinal tract.
Claims26
A method of inhibiting or reducing methanogenesis, or reducing or eliminating enteric methane production comprising administering an effective amount of an anti-methanogenic lovastatin analog or derivative to a subject in need thereof.
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A method of treating constipation, constipation-associated IBS (IBS-C) and/or chronic idiopathic constipation (CIC), comprising administering an effective amount of an anti-methanogenic lovastatin analog or derivative to a subject in need thereof.
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A modified-release formulation comprising at least one anti-methanogenic lovastatin analog or derivative, wherein the formulation releases at least 60% of the anti-methanogenic lovastatin analog or derivative after the stomach and into one or more regions of the intestinal tract.
19-55. (canceled)
58-68. (canceled)
Dependencies are inferred from the claim text.