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US 2023/0398089 A1Published application
Sustained-release formulation composition
AssigneeNanjing Delova Biotech Co., Ltd.
InventorsLing LI, Qu WU, Yuanxin JI, Qingsong WANG
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Abstract
An oil gel pharmaceutical composition, contains a liquid oil, a pharmaceutically acceptable gelator, a pharmaceutically acceptable stabilizer, and a pharmaceutically active component. The pharmaceutical composition is particularly suitable for a pharmaceutical preparation having anesthetic and analgesic activity, has good release duration and stability, can be used for injection and topical administration, has good patient tolerance and very few side effects.
Claims10
A pharmaceutical composition, comprising the following components:
- a. a liquid oil
- b. a pharmaceutically acceptable gelator, selected from one or more of fatty acid glycerides of formula I:
- wherein R′ and R″ may be identical or different and are each independently selected from H or RaCO, and R′″ is selected from RaCO;
- each Ra is independently selected from saturated or unsaturated aliphatic hydrocarbyl;
- c. a pharmaceutically acceptable stabilizer, selected from one or more of compounds of formula II or formula III:
- the compound of formula II being
- wherein Rs is selected from H,
- R1 and R2 are identical or different and are each independently selected from saturated or unsaturated aliphatic hydrocarbyl;
- R3, R4 and R5 are identical or different and are each independently selected from H or alkyl;
- L is selected from alkylene;
- the compound of formula III being
- wherein R is selected from alkyl;
- and
- d. at least one pharmaceutically active ingredient.
11 more elements
Dependencies are inferred from the claim text.