Method of treating cancer using selective estrogen receptor modulators
AssigneeDuke University
InventorsSuzanne E. Wardell, Erik R. Nelson, Donald P. McDonnell
Life of this patent
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Abstract
Disclosed herein are methods of treating subjects suffering from estrogen receptor positive cancer of the brain by administering a selective estrogen receptor degrader (SERM). Also disclosed are methods of treating a cancer that is resistant to an estrogen receptor modulator by administering a SERM.
Claims15
1-23. (canceled)
A method of treating estrogen receptor positive breast cancer brain metastasis in a subject, the method comprising administering a compound of (R)-6-{2-{ethyl[4-(2-ethylaminoethyl) benzyl]amino}-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-ol, wherein the estrogen receptor positive breast cancer brain metastasis is resistant to an aromatase inhibitor.
A method of treating estrogen receptor positive breast cancer brain metastasis in a subject, the method comprising administering a composition comprising (R)-6-{2-{ethyl[4-(2-ethylaminoethyl) benzyl]amino}-4-methoxyphenyl}-5,6,7,8-tetrahydronaphthalen-2-ol, wherein the estrogen receptor positive breast cancer brain metastasis is resistant to an aromatase inhibitor.
Dependencies are inferred from the claim text.