Photocatalytic system for enantio-selective enrichment
OwnerYaron PAZ, Nitai ARBELLinventors
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Abstract
The present disclosure concerns catalytic systems for stereo-selective enrichment, more specifically enantio-selective templated catalytic units that are used for selective enrichment of stereoisomers, in particular enantiomers, in a mixture. The catalytic systems are based on forming chiral-specific active molecular cavities onto the surface of a photocatalytic substrate, such as titania, that are tailored to interact with a specific enantiomer, while a non-photocatalytic coating layer prevents interaction in other areas of the catalyst's surface.
Claims29
A photocatalytic unit for increasing the relative amount of at least one first stereoisomer of a compound with respect to at least one second stereoisomer of the compound in a mixture comprising said first and second stereoisomers, the unit having
- a photocatalytic substrate comprising at least one photocatalyst,
- at least one non-photocatalytic coating layer substantially coating said photocatalytic substrate, and
- a plurality of spaced-apart open molecular cavities defined at an external surface of the unit, the cavities being sized and shaped to correspond to a size and shape of said second stereoisomer, each of the cavities having at least a base portion thereof constituted by said photocatalytic substrate.
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A process of preparing a photocatalytic unit for increasing the relative amount of at least one first stereoisomer of a compound with respect to at least one second stereoisomer of the compound in a mixture comprising said first and second stereoisomers, said method comprising:
- (a) associating molecules of said second stereoisomer onto a surface of a photocatalytic substrate that comprises at least one photocatalyst;
- (b) selectively coating said surface by at least one non-photocatalytic material to obtain a non-photocatalytic coating layer on the photocatalytic substrate without substantially overcoating said second stereoisomer molecules;
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- (c) applying conditions onto the coated photocatalytic substrate to degrade said molecules of second stereoisomer, thereby obtaining a photocatalytic unit comprising a photocatalytic substrate that comprises at least one photocatalyst, at least one non-photocatalytic coating layer substantially coating said photocatalytic substrate, with a plurality of spaced-apart open molecular cavities defined at an external surface of the unit, the cavities being sized and shaped to correspond to a size and shape of said second enantiomer, each of the cavities having at least a base portion thereof constituted by said photocatalytic substrate and sidewalls extending from the base portion towards an opening of the cavity, the sidewalls being substantially defined within said non-photocatalytic coating layer.
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A process of preparing a photocatalytic unit for increasing the relative amount of at least one first stereoisomer of a compound with respect to at least one second stereoisomer of the compound in a mixture comprising said first and second stereoisomers, said method comprising:
- (a′) preparing a photocatalytic substrate that comprises at least one photocatalyst having molecules of said second stereoisomer at least partially embedded into onto a surface of said substrate;
- (b′) selectively coating said surface by at least one non-photocatalytic material to obtain a non-photocatalytic coating layer on the photocatalytic substrate without substantially overcoating said second stereoisomer molecules;
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- (c′) applying conditions onto the coated photocatalytic substrate to degrade said molecules of second stereoisomer, thereby obtaining a photocatalytic unit comprising a photocatalytic substrate comprising at least one photocatalyst, at least one non-photocatalytic coating layer substantially coating said photocatalytic substrate and a plurality of spaced-apart open molecular cavities defined at an external surface of the unit, the cavities being sized and shaped to correspond to a size and shape of said second stereoisomer, each of the cavities having at least a base portion thereof constituted by said photocatalytic substrate and sidewalls extending from the base portion towards an opening of the cavity, the sidewalls having a bottom portion formed in said photocatalytic substrate and a top portion formed in said non-photocatalytic coating layer.
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Dependencies are inferred from the claim text.