Methods and systems for isomeric separation using mesoporous graphitized carbon
OwnerYehia Mechref, Alireza Banazadeh +3inventors
InventorsYehia Mechref, Alireza Banazadeh, Sakshi Gautam, Byeong Gwan Cho, Mona Goli
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Abstract
A method, system, and apparatus for chromatography comprises a chromatographic system can include a column packed with mesoporous graphitized carbon (MGC). The MGC serves as an ideal stationary phase and facilitates the efficient isomeric separation of compounds such as permethylated glycans with unprecedented 10 mm long column. The column is anticipated to be an efficient and economical replacement for nanoflow PGC column which was phased out by the manufacturer due to poor performance and lack of reproducibility.
Claims20
A chromatography system comprising:
- a column;
- a stationary phase comprising mesoporous graphitized carbon;
- and
- frit inserted in the column.
A chromatography method comprising:
- packing a column with a stationary phase comprising mesoporous graphitized carbon;
- introducing a mobile phase in the column;
- separating constituent elements in the mobile phase;
- and
- identifying the constituent elements in the mobile phase.
A chromatography system comprising:
- a column comprising a pulled capillary nanospray emitter column;
- a stationary phase comprising mesoporous graphitized carbon;
- frit inserted in the column;
- and
- a heater configured for controlling a temperature of the pulled capillary nanospray emitter column.
Dependencies are inferred from the claim text.