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US 2023/0390403 A1Published application
Compositions and methods for drug delivery
AssigneeNorth Carolina State University
InventorsYevgeny Brudno, Sharda Pandit, Sandeep Palvai, Tiffany Ferrell, Joshua G. Pierce, Nicholas Massaro, Chris Moody
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Abstract
Disclosed herein are methods for drug delivery, as well as kits for drug delivery.
Claims22
A method for delivering an active agent to a target tissue in a subject, the method comprising:
- contacting the target tissue with a therapeutically effective amount of a compound defined by Formula I
- X-L1-CM1 Formula I
- wherein
- X represents a tissue binding moiety;
- L1 is absent, or represents a linking group;
- and
- A represents an active agent
- wherein the tissue binding moiety comprises a functional group capable of chemically reacting with the target tissue to form a covalent bond.
5 more elements
A method of maintaining or reducing the size of a tumor in a subject in need thereof, comprising the steps of:
- (i) injecting into the tumor a therapeutically effective amount of a compound defined by Formula I
- X-L1-CM1 Formula I
- wherein
- X represents a tissue binding moiety;
- L1 is absent, or represents a linking group;
- and
- A represents an active agent
- thereby maintaining or reducing the size of the tumor in the subject
- wherein the tissue binding moiety comprises a functional group capable of chemically reacting with tissue to form a covalent bond.
6 more elements
Dependencies are inferred from the claim text.