Rapidly released bioorthogonal caging groups
AssigneeUniversity of Utah Research Foundation
InventorsRaphael Franzini, Julian Tu
Life of this patent
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Abstract
Bioorthogonal molecules are disclosed and described. A bioorthogonal a molecule having a structure according to: where R2, R3, and R4 are independently selected from H, a substituted or unsubstituted C1-C4 alkyl or alkylene group, a substituted or unsubstituted aryl, COOR9, COR9, CONR9R10, CN, CF3, SO2R9, or a tether molecule; R1 is —R5, —OCOR6, —COR7, or —R8; R5 is —R8, —OH, or tosyl; R6 is a nitrophenyl ether or —R8; R7 is —R8; R8 is a payload or a molecular linker to a payload; and R9 and R10 are independently selected from H or a substituted or unsubstituted C1-C4 alkyl or alkene group.
Claims1
A bioorthogonal molecule, comprising:
- a molecule having a structure according to:
- where R2, R3, and R4 are independently selected from H, a substituted or unsubstituted C1-C4 alkyl or alkylene group, a substituted or unsubstituted aryl, COOR9, COR9, CONR9R10, CN, CF3, SO2R9, or a tether molecule;
- R1 is —R5, —OCOR6, —COR7, or —R8;
- R5 is —R8, —OH, or tosyl;
- R6 is a nitrophenyl ether or —R8;
- R7 is —R8;
- R8 is a payload or a molecular linker to a payload;
- and
- R9 and R10 are independently selected from H or a substituted or unsubstituted C1-C4 alkyl or alkene group.
Dependencies are inferred from the claim text.