Method of treatment of cancer or tumour
AssigneeAdaptimmune Limited
InventorNicholas Jonathan Pumphrey
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Abstract
The present invention relates to a method of treating, preventing or delaying the progression of cancer and/or tumour in a subject comprising administering to the subject a treatment regimen comprising an effective amount of modified immunoresponsive cells expressing or presenting a heterologous T-cell receptor (TCR) having the property of binding to Fetoprotein (AFP) or antigenic peptide thereof, in particular the treatment of Hepatocellular carcinoma (HCC).
Claims34
A method of treating, preventing or delaying the progression of cancer and/or tumour in a subject comprising administering to the subject a treatment regimen comprising an effective amount of modified immunoresponsive cells expressing or presenting a heterologous T-cell receptor (TCR) which binds a peptide antigen of alpha fetoprotein (AFP) comprising FMNKFIYEI (SEQ ID No:
- 1) or residues 158-166 derived from alpha fetoprotein (AFP) SEQ ID NO:
- 51.
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Dependencies are inferred from the claim text.