Bicarbonate as a Potentiator for Antimicrobial Agents
AssigneeMcMaster University
InventorsEric Brown, Maya Farha, Craig MacNair
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Abstract
Provided herein are methods and compositions for modulating a microorganism's response to an antimicrobial agent. In one embodiment, the method comprises contacting the microorganism with an antimicrobial agent and bicarbonate. In one embodiment, provided herein are methods for treating a microbial infection comprising administering to a subject in need an effective amount of (i) bicarbonate and (ii) an antimicrobial agent. Also provided herein are methods of screening for antimicrobial compounds.
Claims18
A method for inhibiting the growth of a bacterium, comprising contacting the bacterium with an effective amount of (i) bicarbonate and (ii) an antimicrobial agent, wherein the antimicrobial agent is azithromycin, and the effective amount of the bicarbonate is a concentration of greater than about 150 mM.
A kit comprising i) a first bicarbonate composition and ii) a second antimicrobial composition, wherein the first composition comprises bicarbonate in an amount of greater than about 150 mM, and the second composition comprises the antimicrobial agent azithromycin.
Dependencies are inferred from the claim text.