N-propargylglycine: a unique inhibitor of proline dehydrogenase with brain-enhancing mitohormesis properties capable of mitigating the pathogenesis of neurodegenerative disorders

Abstract

In certain embodiments, methods of activating the mitochondrial unfolded protein response (UPRmt) and inducing mitohormesis in the brain and/or central nervous system of a mammal are provided where the methods can involve administering to the mammal an effective amount of N-proparglyglycine (N-PPG). In certain embodiments, the mammal is a mammal with a neurodegenerative disease and the method provides for the treatment or prophylaxis of the neurodegenerative disease.

Dependencies are inferred from the claim text.