Transdermal psychoactive alkaloid composition and preparation thereof
AssigneePsilo Scientific Ltd.
InventorsRyan MOSS, Benjamin LIGHTBURN, Lisa RANKEN
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Abstract
A transdermal psychoactive alkaloid composition including a psychoactive alkaloid extract or synthetic psychoactive alkaloid. The alkaloids in the extract are predominantly dephosphorylated rather than phosphorylated. The transdermal psychoactive alkaloid composition also includes an alcohol carrier, a permeation enhancer, a thickener or gelling agent, and optional further excipients. A process for obtaining a transdermal psychoactive alkaloid composition includes dephosphorylating the alkaloid during extraction, purifying the extracted alkaloid, and standardizing it to a specific concentration by adding measured quantities of excipients.
Claims36
A transdermal psychoactive alkaloid composition comprising, by weight:
- 0.1-40% of a psychoactive alkaloid component;
- 1-30% of alcohol;
- 1-80% of one or more permeation enhancers;
- and
- 1-20% of one or more thickening agents, one or more gelling agents or both one or more thickening agents and one or more gelling agents.
A process for obtaining a transdermal psychoactive alkaloid composition, the process comprising:
- extracting psychoactive alkaloid from a dried powdered psychoactive alkaloid source using an acidified solvent with a pH of 3.5 or lower, to obtain a psychoactive alkaloid liquid;
- adjusting the pH of the psychoactive alkaloid liquid to a pH ranging from 3.5-4.5;
- evaporating the solvent from the psychoactive alkaloid liquid to obtain a psychoactive alkaloid extract with more dephosphorylated psychoactive alkaloid than phosphorylated psychoactive alkaloid;
- and
- mixing the psychoactive alkaloid extract with alcohol, at least one permeation enhancer, and at least one thickening or gelling agent to obtain the transdermal psychoactive alkaloid composition.
Dependencies are inferred from the claim text.