Multimodal physiological sensing systems and methods

A system comprising:

• a sensing system comprising;
• an arrangement of electrophysiological sensors and ultrasound transducer modules on a flexible sheet adapted to be placed on an outer surface of a patient's body, the electrophysiological sensors configured to measure electrophysiological signals from the body surface, and the ultrasound transducer modules configured to measure acoustic waves from the body surface and provide respective ultrasound images;
• a remote system coupled to the sensing system through a communication link, the remote system comprising:
• one or more non-transitory machine readable media to store data and instructions, the data comprising ultrasound image data representative of the respective ultrasound images provided by the ultrasound transducer modules, electrophysiological data representative of the electrophysiological signals measured from the body surface, and geometry data representing a spatial relationship between the electrophysiological sensors and patient anatomy in a three-dimensional coordinate system, the geometry data being determined based on the ultrasound image data;
• and
• a processor to access the media and execute the instructions to perform a method comprising:
• analyzing at least one of the ultrasound image data and the electrophysiological data;
• and
• providing output data to visualize physiological information for the patient based on the analysis.

A multimodal sensing apparatus, comprising:

• a solid state transducer configured to at least sense acoustic energy from a transducer location;
• circuitry coupled to the transducer;
• an electrophysiological sensor coupled to the circuitry, the sensor configured to at least sense electrophysiological signals from a sensor location, in which the sensor location has a known spatial position relative to the transducer location;
• and
• a monolithic substrate carrying the solid state transducer, the circuitry and the electrophysiological sensor.