Methods and systems for chemoautotrophic production of organic compounds
AssigneeGinkgo Bioworks, Inc.
InventorsCurt R. Fischer, Austin J. Che, Reshma P. Shetty, Jason R. Kelly
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Abstract
The present disclosure identifies pathways, mechanisms, systems and methods to confer chemoautotrophic production of carbon-based products of interest, such as sugars, alcohols, chemicals, amino acids, polymers, fatty acids and their derivatives, hydrocarbons, isoprenoids, and intermediates thereof, in organisms such that these organisms efficiently convert inorganic carbon to organic carbon-based products of interest using inorganic energy, such as formate, and in particular the use of organisms for the commercial production of various carbon-based products of interest.
Claims21
1-31. (canceled)
A host cell that comprises a heterologous polynucleotide encoding a 6-phospho-3-hexuloisomerase (PHI), wherein the polynucleotide comprises a sequence that is at least 90% identical to SEQ ID NO:
- 48.
A polynucleotide comprising a sequence that is at least 90% identical to SEQ ID NO:
- 48.
A host cell that comprises a heterologous polynucleotide encoding a 6-phospho-3-hexuloisomerase (PHI), wherein the PHI comprises a sequence that is at least 90% identical to the Escherichia coli PHI protein encoded by SEQ ID NO:
- 48, wherein the PHI protein encoded by SEQ ID NO:
- 48 corresponds to NCBI Reference Sequence YP_115431.
Dependencies are inferred from the claim text.