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AssigneesVersitech Limited, Advanced Biomedical Instrumentation Centre Limited
InventorsShing Fung CHOW, Kam Hung LOW, Si Nga WONG
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The subject invention pertains to cocrystals of dexamethasone (DEX) and a benzenediol cocrystal composed of a 1:1 molar ratio of DEX and the benzenediol. The benzenediol can be catechol (CAT) or resorcinol (RES). The DEX and benzenediol cocrystal are formed by grinding crystalline DEX where the crystalline benzenediol are combined in the 1:1 molar ratio. Grinding can be performed at room temperature. Cocrystals can be thermally annealed or exposed to humidity to enhance cocrystal formation. The DEX−CAT or DEX-RES cocrystals can be included in a medicament for use in treatments for allergies, asthma, rhinitis, cancer, diabetes, anemia, ulcers, and viral infections. The DEX−benzenediol cocrystal can be sieved to provide particles that are in the range of 10 to 45 μm that can be used for intranasal administration with improved dissolution performance.
A cocrystal of dexamethasone (DEX), comprising DEX and at least one coformer wherein the coformer comprises a plurality of hydrogen-bonding functional groups.
A method of preparing a cocrystal of the DEX and a coformer, comprising:
A medicament comprising a cocrystal of DEX and a benzenediol in a 1:1 molar ratio of DEX to the benzenediol.
Dependencies are inferred from the claim text.