Urea monitoring during dialysis for improved quality control and treatment guidance
AssigneeUniversity of Iowa Research Foundation
InventorsMark Arnold, Jonathon Olesberg
Life of this patent
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Abstract
A method of measuring a dialysis efficacy, dialysis dose, and impacts of dialysis on a patient. The method including measuring a concentration of urea in a dialysis effluent over time; determining a rate of change in urea concentration; and determining the rate of peripheral perfusion from the rate of change in urea concentration. The concentration of urea may be taken in real time or near-real time. The method including determining changes in the rate of peripheral perfusion in real time or near real-time. The method including detecting disequilibrium between the core and peripheral blood and early onset of clinically adverse conditions.
Claims20
A method of measuring efficacy and impacts of dialysis comprising:
- measuring a concentration of urea in a dialysis effluent over time;
- determining a rate of change in urea concentration;
- and
- identifying a rate of peripheral perfusion and changes in the rate of peripheral perfusion from the rate of change in urea concentration in real-time or near real-time.
A system for monitoring dialysis, comprising:
- (a) a dialysis machine;
- (b) a urea monitoring sensor disposed on the dialysis machine, the urea monitoring sensor configured to measure a concentration of urea over time;
- and
- (c) a processor in communication with the urea monitoring sensor,
- wherein the processor determines a rate of change in the concentration of urea over time, and wherein the processor determines a rate of peripheral perfusion.
The system of any of claims 10-13, wherein the urea monitoring sensor is located adjacent to a dialyzer of the dialysis machine.
The system of any of claims 10-14, further comprising an ultrafiltration port and wherein the urea monitoring sensor is configured to measure urea concentration in a blood ultrafiltrate from the ultrafiltration port.
The system of any of claims 10-15, wherein the rate of peripheral perfusion can be determined from the equation:
- U
-
- (
- t
- )
- =
- U
- 0
-
- exp
-
- (
- -
- Kt
- V
- eff
- (
- t
- )
- )
- ,
- where U is a concentration of urea,
- where K is a dialyzer clearance value,
- where t is a time from start of dialysis, and
- where Veff(t) is an effective patient volume being cleared of urea at a given time.
A method of measuring peripheral perfusion during hemodialysis comprising:
- measuring urea concentration in used dialysate;
- generating a urea concentration profile;
- determining a rate of change in urea concentration over time;
- and
- determining a rate of peripheral perfusion from the following equation:
- U
-
- (
- t
- )
- =
- U
- 0
-
- exp
-
- (
- -
- Kt
- V
- eff
- (
- t
- )
- )
- ,
- where U is a concentration of urea,
- where K is a dialyzer clearance value,
- where t is a time from start of dialysis, and
- where Veff(t) is an effective patient volume being cleared of urea at a given time.
Dependencies are inferred from the claim text.