Novel angiotensin i-converting enzyme (ace) inhibitory peptides
AssigneeThai Union Group Public Company Limited
InventorTidarat Toopcham
Life of this patent
Estimating the term…
Abstract
The present disclosure provides fish-derived peptides with ACE inhibitory activity, and methods of producing peptide isolates comprising the fish-derived peptides. The present disclosure also provides pharmaceutical products, dietary supplements, and functional foods including the peptide isolates, and method of lowering blood pressure of a subject by administering to the subject one or more of the fish-derived peptides.
Claims18
1-31. (canceled)
A method of producing a peptide isolate, comprising the steps of:
- mixing fish meat with water to produce an aqueous mixture;
- adjusting the pH of the aqueous mixture to a basic pH;
- hydrolyzing the fish meat by adding an alkaline protease to the aqueous mixture and incubating the aqueous mixture under conditions sufficient to produce a hydrolysate, wherein the peptide isolate comprises at least one peptide consisting of the amino acid sequence selected from:
- VIYSR (SEQ ID NO:
- 6), INCR (SEQ ID NO:
- 7), and SRINCR (SEQ ID NO:
- 8).
A method of treating hypertension in a subject in need thereof comprising administering to the subject a peptide, wherein the peptide consists of the amino acid sequence selected from:
- VIYSR (SEQ ID NO:
- 6), INCR (SEQ ID NO:
- 7), and SRINCR (SEQ ID NO:
- 8).
Dependencies are inferred from the claim text.