Radiopharmaceutical products

A method of preparation of an imaging agent product, the imaging agent product comprising a radiopharmaceutical composition supplied within a sealed container, wherein:

• (A) said radiopharmaceutical composition comprises a radioisotope suitable for medical imaging provided in a biocompatible carrier, in a form suitable for mammalian administration;
• (B) said sealed container is provided with a closure suitable for puncturing with a hypodermic needle whilst maintaining seal integrity, and said closure is coated on those of its surface(s) which are in contact with the container contents with a coating comprising ethylene-tetrafluoroethylene copolymer (ETFE) or modified versions thereof;
• the method of preparation comprises reaction of:
• (i) a precursor comprising a reactive substituent (XR) capable of reaction with a supply of a radioisotope;
• with
• (ii) a supply of the radioisotope;
• to make said radiopharmaceutical composition as a reaction product,
• wherein either the reaction is in the sealed container, or the reaction is in a separate reaction vessel followed by transfer of the reaction product to the sealed container.