Compositions and methods for treating serrated colorectal cancer
AssigneeSanford Burnham Prebys Medical Discovery Institute
InventorsJorge Moscat-Guillen et al., Matia T. Diza-Meco Conde, Maria Angeles Duran-Molina, Yuki Nakanishi
Life of this patent
Estimating the term…
Abstract
Disclosed herein are methods for identifying a subject as having serrated colorectal cancer (CRC), and models of human serrated CRC. Also provided herein are methods for treating serrated CRC in the subject.
Claims27
A method of treating a serrated tumor in a subject, comprising:
- administering to the subject a therapeutically effective amount of an inhibitor of hyaluronan activity or expression, wherein a biological sample from the subject has lower levels of expression of PKCζ and PKC /ι compared to levels of expression of PKCζ and PKC /ι in an individual without a serrated tumor.
The method of claim 2, wherein the inhibitor of hyaluronan activity or expression comprises a small molecule.
6-7. (canceled)
9-10. (canceled)
(canceled)
15-19. (canceled)
A method of treating a serrated tumor in a subject, comprising:
- administering to the subject a therapeutically effective amount of an inhibitor of hyaluronan activity or expression.
(canceled)
29-31. (canceled)
(canceled)
Dependencies are inferred from the claim text.