Method for producing peptide, protective group-forming reagent, and condensed polycyclic compound
AssigneeFUJIFILM Corporation
InventorHiroaki TSUYAMA
Life of this patent
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Abstract
An object of the present invention is to provide a method for producing a peptide with high purity and high efficiency, a protective group-forming reagent having excellent deprotective properties, and a novel condensed polycyclic compound. According to the present invention, there are provided a method for producing a peptide including a step of using a polycyclic compound represented by Formula (1), a protective group-forming reagent containing the polycyclic compound, and the polycyclic compound. At least one of R1 to R8 and R110 has RA, RA represents an aliphatic hydrocarbon group or an organic group having an aliphatic hydrocarbon group, and at least one aliphatic hydrocarbon group has 3 or more carbon atoms.
Claims13
A method for producing a peptide, comprising:
- a step of using a polycyclic compound represented by Formula (1),
- in Formula (1), Y1 represents —OR17, —NHR18, —NHCOR18, —SH, or a halogen atom, where R17 represents a hydrogen atom, an active ester-type carbonyl group, or an active ester-type sulfonyl group, and R18 represents a hydrogen atom, an alkyl group, an arylalkyl group, a heteroarylalkyl group, or a chemical structure having a protected or unprotected amino group and a carboxy group,
- Y2 represents —O—, —S—, —CR100=CR101—, —CR102R103—CR104R105—, —CR106R107—, or —N(R110)—, where R100 to R107 each independently represent a hydrogen atom or an alkyl group, and R110 represents RA or a hydrogen atom,
- R1 to R8 each independently represent RA, a hydrogen atom, a halogen atom, an alkyl group, or an alkoxy group, where at least one of R1 to R8 and R110 is RA, and
- RA's each independently represent an aliphatic hydrocarbon group or an organic group having an aliphatic hydrocarbon group, where at least one aliphatic hydrocarbon group has 3 or more carbon atoms.
A protective group-forming reagent of a side chain amino of arginine or glutamine, comprising:
- a polycyclic compound represented by Formula (1),
- in Formula (1), Y1 represents —OR17, —NHR18, —SH, or a halogen atom, where R17 represents a hydrogen atom, an active ester-type carbonyl group, or an active ester-type sulfonyl group, and R18 represents a hydrogen atom, an alkyl group, an arylalkyl group, or a heteroarylalkyl group,
- Y2 represents —O—, —S—, —CR100=CR101—, —CR102R103—CR104R105—, —CR106R107—, or —N(R110)—, where R100 to R107 each independently represent a hydrogen atom or an alkyl group, and R110 represents RA or a hydrogen atom,
- R1 to R8 each independently represent RA, a hydrogen atom, a halogen atom, an alkyl group, or an alkoxy group, where at least one of R1 to R8 and R110 is RA, and
- RA represents an aliphatic hydrocarbon group or an organic group having an aliphatic hydrocarbon group, where at least one aliphatic hydrocarbon group has 3 to 10 carbon atoms.
A polycyclic compound represented by Formula (1),
- in Formula (1), Y1 represents —OR17, —NHR18, —NHCOR18, —SH, or a halogen atom, where R17 represents a hydrogen atom, an active ester-type carbonyl group, or an active ester-type sulfonyl group, and R18 represents a hydrogen atom, an alkyl group having 10 or less carbon atoms, an arylalkyl group, a heteroarylalkyl group, or a chemical structure having a protected or unprotected amino group and a carboxy group,
- Y2 represents —O—, —S—, —CR100=CR101—, —CR102R103—CR104R105—, —CR106R107—, or —N(R110)—, where R100 to R107 each independently represent a hydrogen atom or an alkyl group, and R110 represents RA or a hydrogen atom,
- R1 to R8 each independently represent RA, a hydrogen atom, a halogen atom, an alkyl group having 1 to 4 carbon atoms, or an alkoxy group having 1 to 4 carbon atoms, at least one of R2 to R7 and R110 is RA, and
- RA represents an aliphatic hydrocarbon group or an organic group having an aliphatic hydrocarbon group, where at least one aliphatic hydrocarbon group has 3 to 10 carbon atoms.
Dependencies are inferred from the claim text.