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AssigneesUniversity of Georgia Research Foundation, Inc., The United States of America as represented by the Secretary of Agriculture
InventorsAmy L. Vincent, Marcus E. Kehrli, Daniel R. Perez, Daniela Rajao
Estimating the term…
Recombinant constructs, influenza viral genomes including the recombinant constructs, influenza viruses including the constructs, and vaccine formulations formed thereof for inducing or increasing an immune response against influenza virus are provided. The compositions typically include a nucleic acid having a nucleic acid sequence encoding IgA-inducing protein (IGIP) polypeptide that can positively regulate IgA expression operably linked to expression of a hemagglutinin or a neuraminidase. When the nucleic acid is expressed by recombinant influenza virus in infected cells, it preferably enhances IgA production against influenza virus. Live attenuated virus expressing IGIP, and methods of use thereof for treating and preventing influenza infections are also provided.
A nucleic acid comprising a nucleic acid sequence encoding an IgA-inducing protein (IGIP) polypeptide and a nucleic acid sequence encoding a hemagglutinin (H) or a neuraminidase (N), operably linked to one or more expression control sequences.
A recombinant virus comprising a genome encoding an IgA-inducing protein (IGIP) polypeptide that can increase IgA and/or IgG expression when expressed in a cell infected by the virus.
A polypeptide comprising the amino acid sequence of SEQ ID NO:31.
Dependencies are inferred from the claim text.