Methods for Treating Cholesterol-Related Diseases
AssigneeHDL Therapeutics
InventorsHollis Bryan Brewer, JR., Michael M. Matin
Life of this patent
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Abstract
The present specification is directed to systems, apparatus and methods for treating lipid-related diseases including homozygous familial hypercholesterolemia, heterozygous familial hypercholesterolemia, ischemic stroke, coronary artery disease, acute coronary syndrome, peripheral arterial disease, or renal arterial disease and its complications, and for treating the progression of Alzheimer's disease using imaging techniques to assess changes in one or more lipid-containing atheroma areas and volumes after serial infusions of delipidated plasma as compared to a baseline
Claims20
A method for treatment of cardiovascular disease in a patient, comprising:
- monitoring changes in one or more blood vessels in the patient;
- based on said monitoring, determining if lipid-containing degenerative material is present in said one or more blood vessels;
- monitoring a degree of blood oxygen delivery;
- based on said determination of lipid-containing degenerative material and degree of blood oxygen delivery, determining a treatment protocol for said cardiovascular disease, wherein the treatment protocol comprises at least one of a placement of a stent in the patient, an administration to the patient of a composition derived from mixing a blood fraction of the patient with a lipid removing agent, or a placement of a stent in the patient together with an administration to the patient of a composition derived from mixing a blood fraction of the patient with a lipid removing agent.
A method for treatment of a lipid-related disease in a patient, comprising:
- administering a diagnostic procedure to the patient configured to monitor one or more blood vessels;
- determining a presence of lipid-containing degenerative material in the one or more blood vessels;
- identifying an extent of the presence of lipid-containing degenerative material and comparing said extent to a predetermined lipid-containing degenerative material range of values;
- identifying a level of fractional flow reserve (FFR) and comparing said level to a predetermined threshold FFR range of values;
- proceeding with a first treatment protocol if said extent of the presence of lipid-containing degenerative material is within a first range and said FFR level is within a second range;
- proceeding with a second treatment protocol if said FFR level is within a third range that is less than the FFR level within a second range;
- proceeding with a third treatment protocol if said extent of the presence of lipid-containing degenerative material is within a fourth range that is less than the first range and if said FFR level is within the first range;
- and
- proceeding with a fourth treatment protocol if said extent of the presence of lipid-containing degenerative material is within a fifth range that is greater than the first range and if said FFR level is within the first range, wherein each of the first treatment protocol, second treatment protocol, third treatment protocol, and fourth treatment protocol are different.
Dependencies are inferred from the claim text.