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US 2023/0352218 A1Published application
Superparamagnetic monodisperse particles and method for the production thereof
AssigneeN-lab Technology Center Pte. Ltd.
InventorsHe-Kuan Luo, Honglei Wang, Kelei Chen
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Abstract
Disclosed herein are monodisperse superparamagnetic beads, having a core-shell structure, and a method for preparing the beads.
Claims41
Monodisperse superparamagnetic beads, having a core-shell structure, said bead comprising:
- a core portion formed from a polystyrene polymeric matrix material, where the polystyrene polymeric matrix material encapsulates a first batch of superparamagnetic Fe3O4 nanoparticles;
- a first shell portion located directly on top of the core portion and formed from a crosslinked polymeric matrix material that is formed from a styrene monomer, a crosslinking monomer and a first functional monomer that has functional groups, where the copolymeric matrix material encapsulates a second batch of superparamagnetic Fe3O4 nanoparticles;
- and
- a second shell portion located directly on top of the first shell portion, which is formed as a first layer, a second layer and a third layer,
- the first layer comprises superparamagnetic Fe3O4 nanoparticles and a first layer polymeric matrix material that comprises a conjugating monomer and a bulk monomer;
- a second layer extending beyond the first layer, which is formed from a second layer polymeric material that comprises a bulk monomer;
- and
- a third layer on top of the second layer, which is formed from a third layer polymeric material that comprises a bulk monomer and a second functional monomer that has functional groups, wherein:
- the superparamagnetic Fe3O4 nanoparticles in the first layer are directly bound to the functional groups present on an outer surface of the first shell portion;
- the first layer polymeric matrix material surrounds the superparamagnetic Fe3O4 nanoparticles in the first layer;
- and
- the second layer polymeric matrix material extends from the first layer polymeric matrix material and forms an outer surface of each monodisperse superparamagnetic bead.
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A method of preparing monodisperse superparamagnetic beads, having a core-shell structure, the method comprising:
- (a) providing monodisperse superparamagnetic precursor beads, which comprise
- a core portion formed from a polystyrene polymeric matrix material, where the polystyrene polymeric matrix material encapsulates a first batch of superparamagnetic Fe3O4 nanoparticles;
- a first shell portion located directly on top of the core portion and formed from a crosslinked polymeric matrix material that is formed from a styrene monomer, a crosslinking monomer and a first functional monomer that has functional groups, where the copolymeric matrix material encapsulates a second batch of superparamagnetic Fe3O4 nanoparticles;
- and
- a second shell portion located directly on top of the first shell portion, which comprises superparamagnetic Fe3O4 nanoparticles and polymeric precursor anchor points, both which are bound to the functional groups on a surface of the first shell portion;
- and
- (b) forming a functional coating layer on the monodisperse superparamagnetic precursor beads by a one-pot free radical polymerization, which:
- (i) in a first step uses a bulk monomer;
- and
- (ii) in a second step uses a second functional monomer that has functional groups to form the monodisperse superparamagnetic beads, wherein
- the functional coating layer is bound to the first shell portion by way of the polymeric precursor anchor points.
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Dependencies are inferred from the claim text.