Methods and compositions for inhibiting and treating neurological conditions
AssigneePopulation Bio, Inc.
InventorsEli HATCHWELL, Peggy S. Eis
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Abstract
This document provides methods and materials related to treating subjects having specific genetic variations associated with neurological disorders such as Parkinson's disease.
Claims21
1-61. (canceled)
A method of hybridizing a nucleic acid probe or synthesizing a nucleic acid product from a sample from a human subject with parkinsonism, the method comprising:
- (a) hybridizing a nucleic acid probe to a polynucleic acid from the sample by nucleic acid hybridization or microarray analysis, or synthesizing a nucleic acid product from a polynucleic acid from the sample by PCR or sequencing;
- and
- (b) detecting a genetic variation from the human subject by the nucleic acid hybridization, microarray analysis, PCR or sequencing,
- wherein the genetic variation is a copy number variation (CNV), wherein the CNV is in a PIK3C3 gene.
A method comprising administering a therapeutic agent that treats or slows the progression of one or more symptoms of parkinsonism to a human subject with parkinsonism, wherein the human subject comprises a genetic variation, wherein the genetic variation is a copy number variation (CNV), and wherein the CNV is in a PIK3C3 gene and wherein a sample from the human subject has been assayed to detect the presence of the genetic variation.
Dependencies are inferred from the claim text.