Psma-targeting compounds and uses thereof

A compound having the structure

• wherein the subunits associated with elements p, q, r, and s may be in any order;
• Z is tetrazole or CO2Q;
• each Q is independently selected from hydrogen or a protecting group, a is 1, 2, 3, or 4;
• R is each independently H or C1-C4 alkyl;
• r is 0 or 1;
• Tz is a triazole group selected from the group consisting of
• L1 is
• L2 is
• X1 is —NRC(O)—, —NRC(O)NR—, —NRC(S)NR—, or —NRC(O)O—;
• X2 is —C(O)NR—, —NRC(O)NR—, —NRC(S)NR—, or —OC(O)NR—;
• R5 is H, CO2H, or CO2R6, where R6 is a C1-C6 alkyl, C2-C12 aryl, or C4-C16 alkylaryl;
• b is 1, 2, 3, or 4;
• d is 1, 2, 3, or 4;
• q is 0 or 1;
• W is —NRC(O)—, —NRC(O)NR—, NRC(S)NR—, —NRC(O)O—, —OC(O)NR—, —OC(O)—, —C(O)NR—, or —C(O)O—
• R2 and R3 are independently H, CO2H, or CO2R4, where R4 is a C1-C6 alkyl, C2-C12 aryl, or C4-C16 alkylaryl, wherein if one of R2 and R3 is CO2H or CO2R2, then the other is H;
• n is 1, 2, 3, 4, 5 or 6;
• s is 0 or 1,
• Y is —C(O)—, —NRC(O)—, —NRC(S)—, —OC(O)—;
• m is 1, 2, 3, 4, 5, or 6;
• p is 0, 1, 2, or 3, and when p is 2 or 3, each R1 may be the same or different;
• R1 is H, C1-C6 alkyl, C2-C12 aryl, or C4-C16 alkylaryl;
• G is a moiety selected from the group consisting of
• where Ch is a metal chelating moiety, optionally including a chelated metal;
• FG is a fluorescent dye moiety which emits in the visible or near infrared spectrum;
• one of A and A1 is Ch and the other is FG;
• V and V are independently —C(O)—, —NRC(O)—, —NRC(S)—, or —OC(O)—;
• and g is 1, 2, 3, 4, 5, or 6;
• with the condition that:
• when G is
• and r is 0, then q and s are both 1;
• when G is
• and r is 0, then q and s are both 0 or both 1;
• when G is
• then p is 0 and R2 is H, and the structure optionally includes a chelated metal ion;
• when G is
• and r is 0, then if p is 0, then one of R2 and R3 is CO2R2, and the other is H;
• and
• when g is
• then r is 0.